PT  - JOURNAL ARTICLE
ED  - Hart, William R.
AU  - Van Lente, Frederick
AU  - Galen, Robert S.
AU  - Castellani, William
AU  - Chou, David
AU  - Matzen, Richard N.
TI  - Sequential investigation of aspartate aminotransferase elevation in outpatients
DP  - 1987 May 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 171--175
VI  - 54
IP  - 3
4099  - http://www.ccjm.org/content/54/3/171.short
4100  - http://www.ccjm.org/content/54/3/171.full
SO  - Cleve Clin J Med1987 May 01; 54
AB  - The authors used a computer-based protocol to evaluate the significance of elevations in aspartate aminotransferase (AST) activity in outpatients undergoing periodic health examinations. The protocol was used to systematically guide the performance of confirming secondary tests when the initial AST activity was elevated. Interpretation of all laboratory results was computer generated by an EXPERT artificial intelligence program developed by the authors. Implementing this system in a laboratory-based accelerated testing program resulted in the investigation of 79 AST elevations in 3,096 outpatients; 93% of these results were confirmed by secondary testing and represented apparent alcohol-induced liver dysfunction, hepatitis (including HBV), unclassified liver dysfunction, muscle insult, or hypothyroidism. This laboratory testing protocol appears to be an attractive alternative to traditional laboratory screening.