PT  - JOURNAL ARTICLE
AU  - Lucas, Fred V.
AU  - Fishleder, Andrew J.
AU  - Becker, Richard C.
AU  - Cavalier, Deborah S.
AU  - Tubbs, Raymond R.
TI  - Acquired factor X deficiency in systemic amyloidosis
DP  - 1987 Sep 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 399--406
VI  - 54
IP  - 5
4099  - http://www.ccjm.org/content/54/5/399.short
4100  - http://www.ccjm.org/content/54/5/399.full
SO  - Cleve Clin J Med1987 Sep 01; 54
AB  - Acquired factor X deficiency has been described in association with primary amyloidosis in a small number of patients. Although readily corrected in vitro by mixing patient plasma with normal plasma, the deficiency is not easily corrected in vivo because transfused factor X is rapidly cleared from the circulation. It has been suggested that the mechanism underlying this phenomenon may be the selective binding of factor X to amyloid and its consequent removal from the circulation. Two cases of primary amyloidosis and coexistent acquired factor X deficiency are reported. Immunostains for factor X and immunoglobulin light chains showed the coagulation factor in the region of the amyloid deposits. The findings directly support the hypothesis that factor X deficiency in primary amyloidosis is caused by clearance of factor X by binding to amyloid fibrils.