PT  - JOURNAL ARTICLE
AU  - Sogal, Ramesh N.
AU  - Gottlieb, Alexandru A.
AU  - Boutros, Azmy R.
AU  - Ganapathi, Ram R.
AU  - Tubbs, Raymond R.
AU  - Satariano, Patricia
AU  - Blakely, Paul R.
AU  - Beck, Gerald J.
TI  - Effect of oxygen on bleomycin-induced lung damage
DP  - 1987 Nov 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 503--508
VI  - 54
IP  - 6
4099  - http://www.ccjm.org/content/54/6/503.short
4100  - http://www.ccjm.org/content/54/6/503.full
SO  - Cleve Clin J Med1987 Nov 01; 54
AB  - Mortality and lung damage resulting from bleomycin-oxygen interaction were studied in mice. No animals died in the control group given saline and breathing 21% to 50% oxygen. Mortality following injection of 10 mg/kg and 20 mg/kg bleomycin, respectively, increased from 0% and 6% following exposure to 21% oxygen, to 20% and 33% after 30% oxygen, and to 47% and 66% after 50% oxygen. Pulmonary pathology also became progressively more severe at the higher oxygen concentrations as measured by pulmonary hydroxyproline content and a visually scored index of cellular pathology.