RT Journal Article
SR Electronic
T1 Effect of oxygen on bleomycin-induced lung damage
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 503
OP 508
VO 54
IS 6
A1 Sogal, Ramesh N.
A1 Gottlieb, Alexandru A.
A1 Boutros, Azmy R.
A1 Ganapathi, Ram R.
A1 Tubbs, Raymond R.
A1 Satariano, Patricia
A1 Blakely, Paul R.
A1 Beck, Gerald J.
YR 1987
UL http://www.ccjm.org/content/54/6/503.abstract
AB Mortality and lung damage resulting from bleomycin-oxygen interaction were studied in mice. No animals died in the control group given saline and breathing 21% to 50% oxygen. Mortality following injection of 10 mg/kg and 20 mg/kg bleomycin, respectively, increased from 0% and 6% following exposure to 21% oxygen, to 20% and 33% after 30% oxygen, and to 47% and 66% after 50% oxygen. Pulmonary pathology also became progressively more severe at the higher oxygen concentrations as measured by pulmonary hydroxyproline content and a visually scored index of cellular pathology.