PT  - JOURNAL ARTICLE
AU  - Vidt, Donald G.
TI  - Alpha-blockers and congestive heart failure: Early termination of an arm of the ALLHAT trial
DP  - 2000 Jun 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 429--433
VI  - 67
IP  - 6
4099  - http://www.ccjm.org/content/67/6/429.short
4100  - http://www.ccjm.org/content/67/6/429.full
SO  - Cleve Clin J Med2000 Jun 01; 67
AB  - The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) is a large, randomized double-blind study comparing four antihypertensive agents (chlorthalidone, doxazosin, amlodipine, and lisinopril) in hypertensive patients older than 55 years. The doxazosin arm was terminated early, when the trial’s safety and monitoring board noted a twofold higher incidence of congestive heart failure in patients receiving doxazosin than in those receiving chlorthalidone (8.13% vs 4.45% at 4 years, P < .001).