RT Journal Article
SR Electronic
T1 Alpha-blockers and congestive heart failure: Early termination of an arm of the ALLHAT trial
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 429
OP 433
VO 67
IS 6
A1 Vidt, Donald G.
YR 2000
UL http://www.ccjm.org/content/67/6/429.abstract
AB The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) is a large, randomized double-blind study comparing four antihypertensive agents (chlorthalidone, doxazosin, amlodipine, and lisinopril) in hypertensive patients older than 55 years. The doxazosin arm was terminated early, when the trial’s safety and monitoring board noted a twofold higher incidence of congestive heart failure in patients receiving doxazosin than in those receiving chlorthalidone (8.13% vs 4.45% at 4 years, P < .001).