PT - JOURNAL ARTICLE AU - Glauser, Jonathan TI - Tricyclic antidepressant poisoning DP - 2000 Oct 01 TA - Cleveland Clinic Journal of Medicine PG - 704--718 VI - 67 IP - 10 4099 - http://www.ccjm.org/content/67/10/704.short 4100 - http://www.ccjm.org/content/67/10/704.full SO - Cleve Clin J Med2000 Oct 01; 67 AB - Tricyclic antidepressant poisoning causes predictable electrocardiographic abnormalities and can be lethal. Cardiac arrhythmias, hypotension, seizures, and coma are common. Sodium bicarbonate is still considered the treatment of choice for severe toxicity, although a variety of supportive measures may be taken. Hypertonic saline appears to be a promising alternative.