RT Journal Article SR Electronic T1 Tricyclic antidepressant poisoning JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 704 OP 718 VO 67 IS 10 A1 Glauser, Jonathan YR 2000 UL http://www.ccjm.org/content/67/10/704.abstract AB Tricyclic antidepressant poisoning causes predictable electrocardiographic abnormalities and can be lethal. Cardiac arrhythmias, hypotension, seizures, and coma are common. Sodium bicarbonate is still considered the treatment of choice for severe toxicity, although a variety of supportive measures may be taken. Hypertonic saline appears to be a promising alternative.