RT Journal Article SR Electronic T1 Solitary pulmonary nodule JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 68 OP 74 VO 55 IS 1 A1 James K. Stoller A1 Muzaffar Ahmad A1 Thomas W. Rice YR 1988 UL http://www.ccjm.org/content/55/1/68.abstract AB The solitary pulmonary nodule remains a common and challenging clinical problem. The goal of diagnosis is to establish the cause of the pulmonary nodule by the least invasive means. The authors thus review the scope of the problem, the differential diagnosis of the solitary pulmonary nodule, the available radiographic diagnostic techniques, and the available tissue sampling techniques.