RT Journal Article SR Electronic T1 Cushing’s syndrome — 1988 JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 329 OP 337 VO 55 IS 4 A1 Leslie R. Sheeler YR 1988 UL http://www.ccjm.org/content/55/4/329.abstract AB Despite major advances in laboratory methods, radiology, and neurosurgery, the evaluation and therapy of Cushing’s syndrome remains a major challenge to clinicians. In a substantial percentage of the patients with Cushing’s syndrome, laboratory and radiologic studies yield data that are confusing or misleading. This paper reviews the various disorders that comprise Cushing’s syndrome and addresses some of the problems in diagnosis and therapy.