PT  - JOURNAL ARTICLE
AU  - Joseph V. Nally, Jr.
AU  - Bharat K. Gupta
AU  - Harry S. Clarke, Jr.
AU  - James T. Higgins, Jr.
AU  - William J. Potvin
AU  - Michael L. Gross
TI  - Captopril renography for the detection of renovascular hypertension
DP  - 1988 Jul 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 311--318
VI  - 55
IP  - 4
4099  - http://www.ccjm.org/content/55/4/311.short
4100  - http://www.ccjm.org/content/55/4/311.full
SO  - Cleve Clin J Med1988 Jul 01; 55
AB  - The effect of a provocative challenge with an angiotensin-converting enzyme inhibitor (captopril) upon technetium-99m-labeled diethylene triaminepentaacetic acid (Tc-99m-labeled DTPA) and iodohippurate sodium 1-131 (1-131 Hippuran) renograms was studied in a group of 16 selected hypertensive patients. The patients were categorized as having either renal artery stenosis (RAS, n= 11) or essential hypertension (EHT, n=5) based upon renal angiographic findings. In patients with RAS, captopril altered the time-activity curves of the stenotic kidney(s) of both radionuclide studies and improved the diagnostic sensitivity. In patients with EHT, captopril did not alter the radionuclide studies. Converting-enzyme inhibition coupled with noninvasive radionuclide studies of the renovascular bed offers promise in improving the sensitivity and specificity for detecting hemodynamically significant RAS in the hypertensive population.