TY - JOUR T1 - Premenstrual dysphoric disorder: A review for the treating practitioner JF - Cleveland Clinic Journal of Medicine JO - Cleve Clin J Med SP - 303 LP - 321 VL - 71 IS - 4 AU - Gurjit Kaur AU - Lilian Gonsalves AU - Holly L. Thacker Y1 - 2004/04/01 UR - http://www.ccjm.org/content/71/4/303.abstract N2 - Premenstrual dysphoric disorder (PMDD), a severe form of premenstrual syndrome (PMS), is characterized by physical and behavioral symptoms that cause marked social impairment during the last half of the menstrual cycle. Symptoms are believed to result from the interaction of central neurotransmitters and normal menstrual hormonal changes. Treatment usually begins with lifestyle changes, over-the-counter medications, and if needed, selective serotonin reup-take inhibitors. Physicians should be aware of the risks of many of the alternative therapies commonly touted in the popular press. ER -