RT Journal Article SR Electronic T1 Premenstrual dysphoric disorder: A review for the treating practitioner JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 303 OP 321 VO 71 IS 4 A1 Gurjit Kaur A1 Lilian Gonsalves A1 Holly L. Thacker YR 2004 UL http://www.ccjm.org/content/71/4/303.abstract AB Premenstrual dysphoric disorder (PMDD), a severe form of premenstrual syndrome (PMS), is characterized by physical and behavioral symptoms that cause marked social impairment during the last half of the menstrual cycle. Symptoms are believed to result from the interaction of central neurotransmitters and normal menstrual hormonal changes. Treatment usually begins with lifestyle changes, over-the-counter medications, and if needed, selective serotonin reup-take inhibitors. Physicians should be aware of the risks of many of the alternative therapies commonly touted in the popular press.