RT Journal Article SR Electronic T1 The evolving treatment of chronic hepatitis C: Where we stand a decade out JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP S3 OP S7 VO 71 IS 5 suppl 3 A1 Saadeh, Sherif A1 Davis, Gary L. YR 2004 UL http://www.ccjm.org/content/71/5_suppl_3/S3.abstract AB The treatment of hepatitis C has evolved rapidly since the identification of the hepatitis C virus (HCV) in 1989. Since the first accepted therapy for HCV infection, recombinant interferon, received marketing approval a little more than a decade ago, it has come to be used in combination with ribavirin for improved rates of sustained virologic response. Recently, pegylated versions of interferon have been developed for use with ribavirin, offering pharmacokinetic advantages and further improvements in response rates over conventional interferon. This article briefly reviews how these evolving regimens for HCV infection have addressed the subtle and singular characteristics of this challenging virus.