PT - JOURNAL ARTICLE AU - Bhakta, Shyam AU - Dunlap, Mark E. TI - Angiotensin-receptor blockers in heart failure DP - 2004 Aug 01 TA - Cleveland Clinic Journal of Medicine PG - 665--673 VI - 71 IP - 8 4099 - http://www.ccjm.org/content/71/8/665.short 4100 - http://www.ccjm.org/content/71/8/665.full SO - Cleve Clin J Med2004 Aug 01; 71 AB - The large Candesartan in Heart Failure Assessment of Reduction in Mortality and Morbidity (CHARM) trial recently found that in patients with heart failure who were similar to those whom clinicians see in everyday practice, the angiotensin-receptor blocker candesartan was not only an acceptable alternative to angiotensin-converting enzyme (ACE) inhibitors, but also was beneficial when added to regimens that already included ACE inhibitors and beta-blockers. Candesartan was beneficial in heart failure patients with or without left ventricular systolic dysfunction.