RT Journal Article SR Electronic T1 Angiotensin-receptor blockers in heart failure JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 665 OP 673 VO 71 IS 8 A1 Bhakta, Shyam A1 Dunlap, Mark E. YR 2004 UL http://www.ccjm.org/content/71/8/665.abstract AB The large Candesartan in Heart Failure Assessment of Reduction in Mortality and Morbidity (CHARM) trial recently found that in patients with heart failure who were similar to those whom clinicians see in everyday practice, the angiotensin-receptor blocker candesartan was not only an acceptable alternative to angiotensin-converting enzyme (ACE) inhibitors, but also was beneficial when added to regimens that already included ACE inhibitors and beta-blockers. Candesartan was beneficial in heart failure patients with or without left ventricular systolic dysfunction.