PT - JOURNAL ARTICLE AU - Julie C. Huang AU - Byron J. Hoogwerf TI - Cholesterol guidelines update: More aggressive therapy for higher-risk patients DP - 2005 Mar 01 TA - Cleveland Clinic Journal of Medicine PG - 253--262 VI - 72 IP - 3 4099 - http://www.ccjm.org/content/72/3/253.short 4100 - http://www.ccjm.org/content/72/3/253.full SO - Cleve Clin J Med2005 Mar 01; 72 AB - The 2004 update to the National Cholesterol Education Program guidelines goes farther than the 2001 version in suggesting an optional low-density lipopro-tein cholesterol (LDL-C) goal of less than 70 mg/dL for patients at “very high risk.” It recommends starting both diet and drug therapy in all patients at high or very high risk whose LDL-C level is above the goal level, with the goal of reducing LDL-C by 30% to 40%. These more aggressive guidelines are based on results of five clinical studies published since 2001.