RT Journal Article SR Electronic T1 Treating depression in a mother of five: What to do when the first step fails JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 501 OP 506 VO 72 IS 6 A1 Tesar, George E. YR 2005 UL http://www.ccjm.org/content/72/6/501.abstract AB What should one do with a depressed patient who does not get better? If depression does not respond to an antidepressant given in adequate doses for an adequate time, logical next steps include increasing the dose, adding a different medication, or adding a nonpharmacologic therapy. Or one can reconsider the diagnosis.