PT - JOURNAL ARTICLE AU - Ali, Aman AU - Zein, Nizar N. TI - Hepatitis C infection: A systemic disease with extrahepatic manifestations DP - 2005 Nov 01 TA - Cleveland Clinic Journal of Medicine PG - 1005--1019 VI - 72 IP - 11 4099 - http://www.ccjm.org/content/72/11/1005.short 4100 - http://www.ccjm.org/content/72/11/1005.full SO - Cleve Clin J Med2005 Nov 01; 72 AB - Mixed cryoglobulinemia, renal syndromes, lymphoproliferative disorders, Sjögren syndrome, porphyria cutanea tarda, and neuropathies are all strongly associated with hepatitis C virus (HCV) infection. Diabetes, thyroid disease, and the presence of autoantibodies in the serum are also linked to HCV, but less strongly. The pathophysiologic basis for most of these syndromes seems immunologic. Cirrhosis and chronic HCV infection seem to be risk factors.