RT Journal Article SR Electronic T1 Hepatitis C infection: A systemic disease with extrahepatic manifestations JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 1005 OP 1019 VO 72 IS 11 A1 Ali, Aman A1 Zein, Nizar N. YR 2005 UL http://www.ccjm.org/content/72/11/1005.abstract AB Mixed cryoglobulinemia, renal syndromes, lymphoproliferative disorders, Sjögren syndrome, porphyria cutanea tarda, and neuropathies are all strongly associated with hepatitis C virus (HCV) infection. Diabetes, thyroid disease, and the presence of autoantibodies in the serum are also linked to HCV, but less strongly. The pathophysiologic basis for most of these syndromes seems immunologic. Cirrhosis and chronic HCV infection seem to be risk factors.