PT  - JOURNAL ARTICLE
AU  - LaRosa, Steven P.
TI  - Use of corticosteroids in the sepsis syndrome: What do we know now?
DP  - 2005 Dec 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 1121--1127
VI  - 72
IP  - 12
4099  - http://www.ccjm.org/content/72/12/1121.short
4100  - http://www.ccjm.org/content/72/12/1121.full
SO  - Cleve Clin J Med2005 Dec 01; 72
AB  - Several lines of evidence support the use of corticosteroids as adjunctive therapy for sepsis. In human trials, high-dose, short-course corticosteroid therapy for sepsis has not shown benefit, but prolonged use of low doses has shown benefit in patients with vasopressor-dependent septic shock. The Corticosteroid Therapy of Septic Shock (CORTICUS) trial is addressing the remaining questions regarding the ideal target population for corticosteroid therapy, as well as the best definition of relative adrenal insufficiency in the critically ill.