RT Journal Article
SR Electronic
T1 Use of corticosteroids in the sepsis syndrome: What do we know now?
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 1121
OP 1127
VO 72
IS 12
A1 LaRosa, Steven P.
YR 2005
UL http://www.ccjm.org/content/72/12/1121.abstract
AB Several lines of evidence support the use of corticosteroids as adjunctive therapy for sepsis. In human trials, high-dose, short-course corticosteroid therapy for sepsis has not shown benefit, but prolonged use of low doses has shown benefit in patients with vasopressor-dependent septic shock. The Corticosteroid Therapy of Septic Shock (CORTICUS) trial is addressing the remaining questions regarding the ideal target population for corticosteroid therapy, as well as the best definition of relative adrenal insufficiency in the critically ill.