PT - JOURNAL ARTICLE AU - Andrew Young AU - Mythri Anil Kumar AU - Prashanthi N. Thota TI - GERD: A practical approach AID - 10.3949/ccjm.87a.19114 DP - 2020 Apr 01 TA - Cleveland Clinic Journal of Medicine PG - 223--230 VI - 87 IP - 4 4099 - http://www.ccjm.org/content/87/4/223.short 4100 - http://www.ccjm.org/content/87/4/223.full SO - Cleve Clin J Med2020 Apr 01; 87 AB - Gastroesophageal reflux disease (GERD) is mainly a clinical diagnosis based on typical symptoms of heartburn and acid regurgitation. Current guidelines indicate that patients with typical symptoms should first try a proton pump inhibitor (PPI). If reflux symptoms persist after 8 weeks on a PPI, endoscopy of the esophagus is recommended, with biopsies taken to rule out eosinophilic esophagitis. This review discusses the evidence for different medical, endoscopic, and surgical therapies and presents a management algorithm.