TY - JOUR T1 - Chronic myelogenous leukemia: The news you have and haven’t heard JF - Cleveland Clinic Journal of Medicine JO - Cleve Clin J Med SP - 913 LP - 926 VL - 68 IS - 11 AU - Matt E. Kalaycio Y1 - 2001/11/01 UR - http://www.ccjm.org/content/68/11/913.abstract N2 - Chronic myelogenous leukemia (CML) can usually be cured by bone marrow transplantation from matched donors. Donor T-cell activity from the graft is critical to maintaining remission. Myeloablation may not be necessary for cure. Non-myeloablative but immunosuppressive preparative regimens allow donor engraftment with less toxicity. Early combination therapy with interferon-alfa and cytarabine was the preferred option for patients who could not undergo bone marrow transplantation. Now, the advent of imatinib mesylate, a specific inhibitor of BCR/ABL tyrosine kinase, promises to change existing treatment paradigms ER -