PT  - JOURNAL ARTICLE
AU  - Burke, Carol A.
AU  - Bauer, William M.
AU  - Lashner, Bret
TI  - Chemoprevention of colorectal cancer: Slow, steady progress
DP  - 2003 Apr 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 346--350
VI  - 70
IP  - 4
4099  - http://www.ccjm.org/content/70/4/346.short
4100  - http://www.ccjm.org/content/70/4/346.full
SO  - Cleve Clin J Med2003 Apr 01; 70
AB  - In population-based observational studies, people had lower rates of colorectal cancer if they were taking various agents, including nonsteroidal anti-inflammatory drugs, calcium, and folate. In placebo-controlled trials in patients with familial adenomatous polyposis and in patients with sporadic colon adenomas, nonsteroidal anti-inflammatory drugs reduced the rates of adenomas, and there is a biologic rationale that they would be effective in reducing colorectal cancer as well. Randomized trials of chemopreventive agents are underway in the general population.