RT Journal Article
SR Electronic
T1 Chemoprevention of colorectal cancer: Slow, steady progress
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 346
OP 350
VO 70
IS 4
A1 Burke, Carol A.
A1 Bauer, William M.
A1 Lashner, Bret
YR 2003
UL http://www.ccjm.org/content/70/4/346.abstract
AB In population-based observational studies, people had lower rates of colorectal cancer if they were taking various agents, including nonsteroidal anti-inflammatory drugs, calcium, and folate. In placebo-controlled trials in patients with familial adenomatous polyposis and in patients with sporadic colon adenomas, nonsteroidal anti-inflammatory drugs reduced the rates of adenomas, and there is a biologic rationale that they would be effective in reducing colorectal cancer as well. Randomized trials of chemopreventive agents are underway in the general population.