RT Journal Article SR Electronic T1 When to wean from a ventilator: An evidence-based strategy JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 389 OP 400 VO 70 IS 5 A1 Frutos-Vivar, Fernando A1 Esteban, Andrés YR 2003 UL http://www.ccjm.org/content/70/5/389.abstract AB It is often unclear when and how to wean patients from mechanical ventilation. We have devised an evidence-based protocol in which patients undergo a 30-minute trial of spontaneous breathing with a T tube or pressure support of 7 cm H2O. Those who can tolerate the trial are extubated, while those who cannot are reconnected to mechanical ventilation but undergo another trial every day until they can be extubated. More study is needed to improve the criteria to predict successful spontaneous breathing and extubation, and to clarify the role of noninvasive ventilation to avoid reintubation.