PT - JOURNAL ARTICLE AU - Anthony J. Furlan TI - Acute stroke therapy: Beyond IV tPA DP - 2002 Sep 01 TA - Cleveland Clinic Journal of Medicine PG - 730--734 VI - 69 IP - 9 4099 - http://www.ccjm.org/content/69/9/730.short 4100 - http://www.ccjm.org/content/69/9/730.full SO - Cleve Clin J Med2002 Sep 01; 69 AB - Although intravenous tissue plasminogen activator (IV tPA) has been approved for treating acute ischemic stroke, it must be given within 3 hours of stroke onset and only after ruling out hemorrhagic stroke by computed tomography. Several medical centers are turning to angiography to guide intra-arterial infusion of thrombolytic agents and mechanical endovascular interventions.