RT Journal Article SR Electronic T1 Acute stroke therapy: Beyond IV tPA JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 730 OP 734 VO 69 IS 9 A1 Anthony J. Furlan YR 2002 UL http://www.ccjm.org/content/69/9/730.abstract AB Although intravenous tissue plasminogen activator (IV tPA) has been approved for treating acute ischemic stroke, it must be given within 3 hours of stroke onset and only after ruling out hemorrhagic stroke by computed tomography. Several medical centers are turning to angiography to guide intra-arterial infusion of thrombolytic agents and mechanical endovascular interventions.