PT - JOURNAL ARTICLE AU - Holly L. Thacker TI - The case for hormone replacement: New studies that should inform the debate DP - 2002 Sep 01 TA - Cleveland Clinic Journal of Medicine PG - 670--678 VI - 69 IP - 9 4099 - http://www.ccjm.org/content/69/9/670.short 4100 - http://www.ccjm.org/content/69/9/670.full SO - Cleve Clin J Med2002 Sep 01; 69 AB - The Women’s Health Initiative found that the risks of hormone replacement therapy (HRT) exceeded its benefits in a large group of older postmenopausal women, but did not consider the efficacy of HRT in relieving vasomotor symptoms. Another recent study found that low-dose HRT was as effective as standard-dose HRT while causing fewer side effects. Smaller studies suggest that HRT may improve depression. HRT is not to be used for cardiovascular risk reduction. Genetic testing may point the way to more rational use of HRT.