RT Journal Article SR Electronic T1 The case for hormone replacement: New studies that should inform the debate JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 670 OP 678 VO 69 IS 9 A1 Holly L. Thacker YR 2002 UL http://www.ccjm.org/content/69/9/670.abstract AB The Women’s Health Initiative found that the risks of hormone replacement therapy (HRT) exceeded its benefits in a large group of older postmenopausal women, but did not consider the efficacy of HRT in relieving vasomotor symptoms. Another recent study found that low-dose HRT was as effective as standard-dose HRT while causing fewer side effects. Smaller studies suggest that HRT may improve depression. HRT is not to be used for cardiovascular risk reduction. Genetic testing may point the way to more rational use of HRT.