RT Journal Article SR Electronic T1 Update on the diagnosis and treatment of human papillomavirus infection JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 948 OP 961 VO 69 IS 12 A1 Zanotti, Kristine M. A1 Belinson, Jerome YR 2002 UL http://www.ccjm.org/content/69/12/948.abstract AB Human papillomaviruses (HPVs) are associated with a spectrum of diseases, ranging from common warts to invasive carcinoma of the genital tract. The clinical manifestations of HPV infection depend on the viral subtype, the immune status of the patient, and environmental co-carcinogens. Infection with HPV is often asymptomatic, which makes viral detection challenging. Current therapies do not reliably eradicate HPV infection, and benign genital warts and genital tract intraepithelial neoplasia often recur after treatment. We discuss the pathogenesis, clinical manifestations, detection, and treatment of HPV infections of the anogenital tract.