RT Journal Article
SR Electronic
T1 A truly deadly quartet: obesity, hypertension, hypertriglyceridemia, and hyperinsulinemia
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 985
OP 989
VO 69
IS 12
A1 Nambi, Vijay
A1 Hoogwerf, Byron J.
A1 Sprecher, Dennis L.
YR 2002
UL http://www.ccjm.org/content/69/12/985.abstract
AB The cluster of hypertriglyceridemia, hyperinsulinemia, obesity, and hypertension markedly increases the risk of coronary artery disease. Although no treatments target this syndrome specifically, treatment of each aspect of the cluster is important. Prevention—weight loss and physical activity—is key.The National Cholesterol Education Program recognizes the importance of the metabolic syndrome and has published guidelines for its diagnosis.Weight loss, physical activity, and treatment of the individual risk factors constitute the main strategies for treatment.For now, the goals and methods of treating hypertension and dyslipidemia are the same in people with the metabolic syndrome as in the general population.Thiazolidinedione drugs increase insulin sensitivity, but their use in the metabolic syndrome is only speculative at present. We recommend they be used only as indicated to treat diabetes mellitus.