RT Journal Article SR Electronic T1 Emphysema in nonsmokers: Alpha 1-antitrypsin deficiency and other causes JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP 928 OP 946 VO 69 IS 12 A1 Lee, Pyng A1 Gildea, Thomas R. A1 Stoller, James K. YR 2002 UL http://www.ccjm.org/content/69/12/928.abstract AB Nonsmokers with signs of emphysema at an earlier age than is typical for emphysema deserve a workup for one of the less common causes of emphysema, which include alpha 1-antitrypsin deficiency, connective tissue diseases, hypocomplementemic urticarial vasculitis syndrome, intravenous drug use, human immunodeficiency virus infection, and several rare metabolic disorders.