PT  - JOURNAL ARTICLE
AU  - Gurm, Hitinder S.
AU  - Hoogwerf, Byron
TI  - The Heart Protection Study: High-risk patients benefit from statins, regardless of LDL-C level
DP  - 2003 Nov 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 991--997
VI  - 70
IP  - 11
4099  - http://www.ccjm.org/content/70/11/991.short
4100  - http://www.ccjm.org/content/70/11/991.full
SO  - Cleve Clin J Med2003 Nov 01; 70
AB  - The landmark Heart Protection Study (Lancet 2002; 360:7–22) found benefit in treating subjects at high risk of a coronary event with simvastatin 40 mg daily, regardless of baseline low-density lipoprotein cholesterol level and in all subgroups, including women and the elderly. The study found no benefit of simvastatin therapy in preventing noncardiac events (eg, dementia, osteoporotic fractures), and no negative effects, such as an increase in cancer, respiratory disease, or suicide.