RT Journal Article
SR Electronic
T1 The use of G-CSF and GM-CSF in bone marrow transplantation
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 291
OP 302
VO 60
IS 4
A2 Vidt, Donald G.
A2 Bakst, Alan
A1 Bolwell, Brian J.
YR 1993
UL http://www.ccjm.org/content/60/4/291.abstract
AB Bone marrow transplantation is accepted as potentially curative therapy for a variety of patients with hematologic malignancies and other disorders. The most important causes of morbidity are infections and bleeding secondary to prolonged cytopenias. Granulocyte colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) have been shown to potentially enhance bone marrow engraftment which has translated into reduced morbidity and mortality. Additionally, growth factors such as G-CSF and GM-CSF may increase numbers of circulating peripheral progenitor cells to serve as the source of "marrow" for transplantation. This review summarizes the current available data using G-CSF and GM-CSF in bone marrow transplantation and discusses potential areas of study with additional cytokines.