RT Journal Article
SR Electronic
T1 Azathioprine vs cyclosporine in recipients of HLA-identical renal allografts
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 206
OP 210
VO 61
IS 3
A1 Gill, Inderbir S.
A1 Hodge, Ernest E.
A1 Novick, Andrew C.
A1 Streem, Stevan B.
A1 Braun, William E.
A1 Paranandi, Lata
YR 1994
UL http://www.ccjm.org/content/61/3/206.abstract
AB BACKGROUND Siblings with identical human leukocyte antigens (HLA) are preferred transplant donors.OBJECTIVE To compare the outcomes in azathioprine-treated and cyclosporine-treated recipients of renal transplants from HLAidentical siblings.METHODS Retrospective review.RESULTS From August 1980 to June 1989, 53 consecutive patients received renal transplants from HLA-identical donors. These patients received prednisone and either azathioprine (n = 26) or cyclosporine (n = 27). A mean of 8.4 years elapsed since transplantation in the azathioprine-treated patients and 4.7 years elapsed in the cyclosporine-treated patients. The 5-year patient and graft survival rates were 100% and 92%, respectively, for azathioprinetreated patients and 9 6% and 83%, respectively, for cyclosporinetreated patients (P = .379 for comparison of graft survival). There was no difference between the two groups in the number of rejections or the time to the first rejection episode. At 5 years after transplantation, cyclosporine-treated patients had a significantly higher median serum creatinine concentration (1.7 mg/dL) than did azathioprine-treated patients (1.3 mg/dL, P = .018). Maintenance steroid therapy was successfully withdrawn in six azathioprinetreated patients and seven cyclosporine-treated patients.CONCLUSIONS Azathioprine and cyclosporine produce equally satisfactory outcomes in this immunologically favored group. The need for continued steroid therapy in these patients requires further study.