PT  - JOURNAL ARTICLE
AU  - Peter G. Katona
TI  - Biomedical engineering in heart-brain medicine: A review
AID  - 10.3949/ccjm.77.s3.08
DP  - 2010 Jul 01
TA  - Cleveland Clinic Journal of Medicine
PG  - S46--S50
VI  - 77
IP  - 7 suppl 3
4099  - http://www.ccjm.org/content/77/7_suppl_3/S46.short
4100  - http://www.ccjm.org/content/77/7_suppl_3/S46.full
SO  - Cleve Clin J Med2010 Jul 01; 77
AB  - New reports have emerged exploring the use of electrical stimulation of peripheral nerves in patients for the treatment of depression, heart failure, and hypertension. Abolishing renal sympathetic nerve activity in resistant hypertension has also been described. Since nerve bundles carry a variety of signals to multiple organs, it is necessary to develop technologies to stimulate or block targeted nerve fi bers selectively. Mathematical modeling is a major tool for such development. Purposeful modeling is also needed to quantitatively characterize complex heart-brain interactions, allowing an improved understanding of physiological and clinical measurements. Automated control of therapeutic devices is a possible eventual outcome.