RT Journal Article
SR Electronic
T1 Hypersensitivity syndrome to antiepileptic drugs: A review including new anticonvulsants
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 239
OP 245
VO 66
IS 4
A2 Donald G. Vidt
A1 Hajo M. Hamer
A1 Harold H. Morris
YR 1999
UL http://www.ccjm.org/content/66/4/239.abstract
AB Anticonvulsant hypersensitivity syndrome, a potentially fatal but rare reaction, manifests as rash, fever, tender lymphadenopathy, hepatitis, and eosinophilia. To manage hypersensitivity syndrome successfully, one must recognize the symptoms early, stop the offending drug immediately, and substitute a safe, alternative anticonvulsant medication. Hypersensitivity syndrome has not been described in patients taking benzodiazepines or the newer anticonvulsants gabapentin or topiramate, and these appear to be safe substitutes for drugs that cause the reaction.