PT  - JOURNAL ARTICLE
ED  - Markman, Maurie
AU  - Jin, Xian Wen
AU  - Cash, Joseph
AU  - Kennedy, Alexander W.
TI  - Human papillomavirus typing and the reduction of cervical cancer risk
DP  - 1999 Oct 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 533--539
VI  - 66
IP  - 9
4099  - http://www.ccjm.org/content/66/9/533.short
4100  - http://www.ccjm.org/content/66/9/533.full
SO  - Cleve Clin J Med1999 Oct 01; 66
AB  - Minor cervical cytologic abnormalities are common, but knowing which low-grade lesions will progress to cervical cancer—and therefore deserve biopsy and excision—is difficult. Since some human papillomavirus (HPV) types are strongly associated with cervical cancer, HPV typing may be a means of determining which patients with minor abnormalities require biopsy and treatment and which need only follow-up smears. This paper reviews the association between cervical cancer and HPV infection, the pathogenesis of HPV infection, the utility of HPV typing in triaging patients with a diagnosis of atypical squamous cells of undetermined significance, and the prospects for the development of an HPV vaccine.