RT Journal Article
SR Electronic
T1 Human papillomavirus typing and the reduction of cervical cancer risk
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 533
OP 539
VO 66
IS 9
A2 Maurie Markman
A1 Xian Wen Jin
A1 Joseph Cash
A1 Alexander W. Kennedy
YR 1999
UL http://www.ccjm.org/content/66/9/533.abstract
AB Minor cervical cytologic abnormalities are common, but knowing which low-grade lesions will progress to cervical cancer—and therefore deserve biopsy and excision—is difficult. Since some human papillomavirus (HPV) types are strongly associated with cervical cancer, HPV typing may be a means of determining which patients with minor abnormalities require biopsy and treatment and which need only follow-up smears. This paper reviews the association between cervical cancer and HPV infection, the pathogenesis of HPV infection, the utility of HPV typing in triaging patients with a diagnosis of atypical squamous cells of undetermined significance, and the prospects for the development of an HPV vaccine.