PT  - JOURNAL ARTICLE
ED  - Francis, Gary S.
AU  - Patel, Vasant B.
AU  - Topol, Eric J.
TI  - The pathogenesis and spectrum of acute coronary syndromes: From plaque formation to thrombosis
DP  - 1999 Oct 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 561--571
VI  - 66
IP  - 9
4099  - http://www.ccjm.org/content/66/9/561.short
4100  - http://www.ccjm.org/content/66/9/561.full
SO  - Cleve Clin J Med1999 Oct 01; 66
AB  - Acute coronary syndromes occur when an unstable atherosclerotic plaque erodes or ruptures, exposing the highly thrombogenic material inside the plaque to the circulating blood and triggering rapid formation of a thrombus that occludes the artery. This understanding is leading to a wide variety of new therapies. It is hoped that further research into the pathogenesis of acute coronary syndromes will lead to more accurate markers of risk and more specific preventions and treatments.