RT Journal Article SR Electronic T1 Pathophysiologic mechanisms linking impaired cardiovascular health and neurologic dysfunction: The year in review JF Cleveland Clinic Journal of Medicine JO Cleve Clin J Med FD Cleveland Clinic SP S40 OP S45 DO 10.3949/ccjm.77.s3.07 VO 77 IS 7 suppl 3 A1 Ki E. Park A1 Carl J. Pepine YR 2010 UL http://www.ccjm.org/content/77/7_suppl_3/S40.abstract AB The nervous system and cardiovascular system have long been known to interact. Only more recently, however, have the mechanisms driving this interaction become more clearly understood. Although many psychological disturbances, including depression and anxiety, are known to predict poor outcomes in patients with cardiovascular disease, other neurologic disturbances, such as migraine and stroke, have been connected to poor cardiovascular outcomes as well. Although these connections were traditionally thought to be due to shared risk factors, recent research has focused on pathophysiologic mechanisms underlying these interactions, including neuroendocrine dysregulation, genetic predisposition, and vascular dysfunction.