RT Journal Article
SR Electronic
T1 Experimental therapies for multiple sclerosis: current status
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 63
OP 74
VO 59
IS 1
A1 Donald E. Goodkin
A1 Richard M. Ransohoff
A1 Richard A. Rudick
YR 1992
UL http://www.ccjm.org/content/59/1/63.abstract
AB Multiple sclerosis is the most common cause of nontraumatic disability affecting young adults in the United States. Its etiology remains unclear, but evidence points to alteration of normal immune system function in the pathogenesis of this illness. This article reviews the results of clinical trials of experimental therapeutic agents in multiple sclerosis. The background and action of each treatment are described, and the clinical experience with each agent is reviewed. Obstacles to evaluating the effectiveness of treatment methods in MS and challenges to the design of future clinical trials and the interpretation of trial outcomes are discussed.