RT Journal Article
SR Electronic
T1 Myelodysplastic syndromes: A practical approach to diagnosis and treatment
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 37
OP 44
DO 10.3949/ccjm.77a.09069
VO 77
IS 1
A1 Afsaneh Barzi
A1 Mikkael A. Sekeres
YR 2010
UL http://www.ccjm.org/content/77/1/37.abstract
AB The myelodysplastic syndromes (MDS) are clonal bone marrow disorders that lead to underproduction of normal blood cells. The consequent cytopenias result in infections and bleeding complications. MDS transform to acute myeloid leukemia in one-third of patients. The number of diagnoses has exploded in the past decade as a result of increased recognition and understanding of the disease and the aging of the population. New therapies can extend life. MDS are now considered the most common form of leukemia, and in some cases deserve immediate intervention. This review describes common presentations of MDS, optimal diagnostic approaches, and therapies for lower- and higher-risk disease.