PT  - JOURNAL ARTICLE
AU  - Amy Schilling
AU  - Rebecca Corey
AU  - Mandy Leonard
AU  - Bijan Eghtesad
TI  - Acetaminophen: Old drug, new warnings
AID  - 10.3949/ccjm.77a.09084
DP  - 2010 Jan 01
TA  - Cleveland Clinic Journal of Medicine
PG  - 19--27
VI  - 77
IP  - 1
4099  - http://www.ccjm.org/content/77/1/19.short
4100  - http://www.ccjm.org/content/77/1/19.full
SO  - Cleve Clin J Med2010 Jan 01; 77
AB  - The US Food and Drug Administration (FDA), concerned about the incidence of acute liver failure due to acetaminophen (Tylenol) overdose, has mandated new labeling on acetaminophen packaging. It is also considering (but has not enacted) reducing the maximum daily dose from 4 g (possibly to 3,250 mg), banning acetaminophen-narcotic combination products, and changing the current maximum single dose of 1 g to prescription status, making 650 mg the highest recommended nonprescription dose. We review the epidemiology, toxicology, and management of acetaminophen overdose and steps the FDA and physicians can take to prevent it.