RT Journal Article
SR Electronic
T1 Acetaminophen: Old drug, new warnings
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 19
OP 27
DO 10.3949/ccjm.77a.09084
VO 77
IS 1
A1 Amy Schilling
A1 Rebecca Corey
A1 Mandy Leonard
A1 Bijan Eghtesad
YR 2010
UL http://www.ccjm.org/content/77/1/19.abstract
AB The US Food and Drug Administration (FDA), concerned about the incidence of acute liver failure due to acetaminophen (Tylenol) overdose, has mandated new labeling on acetaminophen packaging. It is also considering (but has not enacted) reducing the maximum daily dose from 4 g (possibly to 3,250 mg), banning acetaminophen-narcotic combination products, and changing the current maximum single dose of 1 g to prescription status, making 650 mg the highest recommended nonprescription dose. We review the epidemiology, toxicology, and management of acetaminophen overdose and steps the FDA and physicians can take to prevent it.