PT - JOURNAL ARTICLE AU - Ben H. Brouhard AU - Barbara Baetz-Greenwalt TI - Calcium-channel blocking agents as therapy for amphotericin B nephrotoxicity DP - 1992 May 01 TA - Cleveland Clinic Journal of Medicine PG - 263--264 VI - 59 IP - 3 4099 - http://www.ccjm.org/content/59/3/263.short 4100 - http://www.ccjm.org/content/59/3/263.full SO - Cleve Clin J Med1992 May 01; 59 AB - Amphotericin B is a broad-spectrum antifungal agent shown to be effective in the treatment of systemic fungal infections. Unfortunately, therapeutic doses are often associated with a variety of adverse effects, including nephrotoxicity. Studies of the deleterious effects of amphotericin B on the renal microvasculature are yielding clues to sparing kidney function. In selected patients, concomitant use of a calcium-channel blocker may prevent the nephrotoxic effects of amphotericin B and allow full therapeutic doses to be used.