RT Journal Article
SR Electronic
T1 Calcium-channel blocking agents as therapy for amphotericin B nephrotoxicity
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 263
OP 264
VO 59
IS 3
A1 Ben H. Brouhard
A1 Barbara Baetz-Greenwalt
YR 1992
UL http://www.ccjm.org/content/59/3/263.abstract
AB Amphotericin B is a broad-spectrum antifungal agent shown to be effective in the treatment of systemic fungal infections. Unfortunately, therapeutic doses are often associated with a variety of adverse effects, including nephrotoxicity. Studies of the deleterious effects of amphotericin B on the renal microvasculature are yielding clues to sparing kidney function. In selected patients, concomitant use of a calcium-channel blocker may prevent the nephrotoxic effects of amphotericin B and allow full therapeutic doses to be used.