RT Journal Article
SR Electronic
T1 Adrenergic agents: clinical trials and experiences
JF Cleveland Clinic Journal of Medicine
JO Cleve Clin J Med
FD Cleveland Clinic
SP 248
OP 254
VO 59
IS 3
A2 Donald G. Vidt
A1 Alan Bakst
A1 Lennart Hansson
YR 1992
UL http://www.ccjm.org/content/59/3/248.abstract
AB Beta-adrenergic blocking agents constitute first-line therapy for hypertension in many countries of the world. Comparative trials have been extensive in duration and have included large numbers of patients. Still, the desired cardioprotective effect of beta blockers has yet to be established. Their antiatherosclerotic effect has been noted in several animal experiments. Confirming evidence is needed before the clinical relevance of this effect can be evaluated, but these studies point to a potential therapeutic effect that may be immensely important in the future. Beta blockers can reverse left ventricular hypertrophy secondary to hypertension, but it remains to be shown that regression of left ventricular hypertrophy will reduce the associated risks.